UFC Undisputed 2010 includes multiple changes from the previous version:
- Improved controls, including a redesign of clinch and ground grappling, as well as an improved career mode, starting in the World Fighting Alliance.
- Changes to gameplay including usage of cage walls, TKO (cut and injury) finishes and the introduction of karate, Greco-Roman wrestling, and Judo fighting styles.
- Added MMA brands for clothing as well as the introduction of post-fight attire.
- New arenas including GM Place, Centre Bell and The O2.
Each fighter on the Undisputed 2010 roster have skills and attributes that can be only viewed while selecting a fighter in expedition mode. Some fighters have different moves than others which can be seen by pausing the game and selecting the controls while using a fighter, again there is no other method to view a fighters moves. Shaquille O’Neal, as well as the Tapout crew from UFC 2009 Undisputed are unlockable fighters.